Dubois Lab

2 PhD positions in bioinformatics and experimental biology

We are looking for two highly motivated PhD candidates (one in bioinformatics and one in experimental biology) interested in investigating how cancer cells change the 3D genome to hijack gene regulation for aberrant expression of oncogenes from high-level genomic amplifications. The bioinformatics part of the project will involve whole genome sequencing and epigenetic analysis of several hundred tumor samples from breast and lung cancer patients to identify significantly recurrent changes to their 3D genome. In the experimental biology part, we will model recurrent oncogenic changes to the 3D genome observed in these cancers using CRISPR-based approaches to understand the mechanism of oncogenic transcription and resulting novel cancer vulnerabilities..

Your responsibilities may include, but are not limited to, the following activities:

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We offer a friendly, collaborative, and fast-paced environment that strives for scientific excellence, investigating clinically impactful questions, and developing each team member. The successful applicant will work closely with an international and interdisciplinary group, including clinicians, bioinformaticians, and biologists. The environment provides many opportunities to learn new skills, and we are deeply committed to excellent mentorship. The pay scale will be the standard 65% E13 PhD contract. We also offer a chance to affiliate with the CompCancer grad school for the bioinformatics PhD student and the BSIO for the experimental biology PhD student.

Please send your application as a single pdf file, including a cover letter indicating your research interests, potential starting date, a curriculum vitae, publication list, and contact information of up to three references to frank.dubois@charite.de.