Dubois Lab

Publications

Highlighted

Structural variations in cancer and the 3D genome
Structural variations in cancer and the 3D genome
Frank Dubois, Nikos Sidiropoulos, Joachim Weischenfeldt, Rameen Beroukhim
Nature Reviews Cancer   ·   28 Jun 2022   ·   doi:10.1038/s41568-022-00488-9
Structural variants shape driver combinations and outcomes in pediatric high-grade glioma
Structural variants shape driver combinations and outcomes in pediatric high-grade glioma
Frank P. B. Dubois, Ofer Shapira, Noah F. Greenwald, Travis Zack, Jeremiah Wala, ..., David T. W. Jones, Mark W. Kieran, Keith L. Ligon, Rameen Beroukhim, Pratiti Bandopadhayay
Nature Cancer   ·   04 Jul 2022   ·   doi:10.1038/s43018-022-00403-z

All

2023

<i>ALK</i> Amplification and Rearrangements Are Recurrent Targetable Events in Congenital and Adult Glioblastoma
ALK Amplification and Rearrangements Are Recurrent Targetable Events in Congenital and Adult Glioblastoma
Anne-Florence Blandin, Ross Giglio, Maya Srikanth Graham, Guadalupe Garcia, Seth Malinowski, ..., Ralf Kittler, Robert Bachoo, Pratiti Bandopadhayay, Rameen Beroukhim, Keith L. Ligon
Clinical Cancer Research   ·   13 Feb 2023   ·   doi:10.1158/1078-0432.CCR-21-3521

2022

Assessing and improving the validity of COVID-19 autopsy studies - A multicentre approach to establish essential standards for immunohistochemical and ultrastructural analyses
Assessing and improving the validity of COVID-19 autopsy studies - A multicentre approach to establish essential standards for immunohistochemical and ultrastructural analyses
Susanne Krasemann, Carsten Dittmayer, Saskia von Stillfried, Jenny Meinhardt, Fabian Heinrich, ..., Frank L. Heppner, Peter Boor, Helena Radbruch, Michael Laue, Markus Glatzel
eBioMedicine   ·   01 Sep 2022   ·   doi:10.1016/j.ebiom.2022.104193
Therapeutic targeting of ATR in alveolar rhabdomyosarcoma
Therapeutic targeting of ATR in alveolar rhabdomyosarcoma
Heathcliff Dorado García, Fabian Pusch, Yi Bei, Jennifer von Stebut, Glorymar Ibáñez, ..., Kerstin Haase, Michela DiVirgilio, Monika Scheer, Michael V. Ortiz, Anton G. Henssen
Nature Communications   ·   25 Jul 2022   ·   doi:10.1038/s41467-022-32023-7
FOXR2 Is an Epigenetically Regulated Pan-Cancer Oncogene That Activates ETS Transcriptional Circuits
FOXR2 Is an Epigenetically Regulated Pan-Cancer Oncogene That Activates ETS Transcriptional Circuits
Jessica W. Tsai, Paloma Cejas, Dayle K. Wang, Smruti Patel, David W. Wu, ..., Claudia L. Kleinman, Henry Long, David T.W. Jones, Pratiti Bandopadhayay, Timothy N. Phoenix
Cancer Research   ·   08 Jul 2022   ·   doi:10.1158/0008-5472.CAN-22-0671
Structural variants shape driver combinations and outcomes in pediatric high-grade glioma
Structural variants shape driver combinations and outcomes in pediatric high-grade glioma
Frank P. B. Dubois, Ofer Shapira, Noah F. Greenwald, Travis Zack, Jeremiah Wala, ..., David T. W. Jones, Mark W. Kieran, Keith L. Ligon, Rameen Beroukhim, Pratiti Bandopadhayay
Nature Cancer   ·   04 Jul 2022   ·   doi:10.1038/s43018-022-00403-z
Structural variations in cancer and the 3D genome
Structural variations in cancer and the 3D genome
Frank Dubois, Nikos Sidiropoulos, Joachim Weischenfeldt, Rameen Beroukhim
Nature Reviews Cancer   ·   28 Jun 2022   ·   doi:10.1038/s41568-022-00488-9
PPM1D mutations are oncogenic drivers of de novo diffuse midline glioma formation
PPM1D mutations are oncogenic drivers of de novo diffuse midline glioma formation
Prasidda Khadka, Zachary J. Reitman, Sophie Lu, Graham Buchan, Gabrielle Gionet, ..., Hasmik Keshishian, Keith L. Ligon, Steven A. Carr, Timothy N. Phoenix, Pratiti Bandopadhayay
Nature Communications   ·   01 Feb 2022   ·   doi:10.1038/s41467-022-28198-8

2020

Histone H3.3G34-Mutant Interneuron Progenitors Co-opt PDGFRA for Gliomagenesis
Histone H3.3G34-Mutant Interneuron Progenitors Co-opt PDGFRA for Gliomagenesis
Carol C.L. Chen, Shriya Deshmukh, Selin Jessa, Djihad Hadjadj, Véronique Lisi, ..., Dominik Sturm, David T.W. Jones, Paolo Salomoni, Claudia L. Kleinman, Nada Jabado
Cell   ·   01 Dec 2020   ·   doi:10.1016/j.cell.2020.11.012
MR Imaging Correlates for Molecular and Mutational Analyses in Children with Diffuse Intrinsic Pontine Glioma
MR Imaging Correlates for Molecular and Mutational Analyses in Children with Diffuse Intrinsic Pontine Glioma
C. Jaimes, S. Vajapeyam, D. Brown, P.-C. Kao, C. Ma, ..., K.L. Ligon, S. Chi, M.W. Kieran, K.D. Wright, T.Y. Poussaint
American Journal of Neuroradiology   ·   01 May 2020   ·   doi:10.3174/ajnr.A6546
Mechanisms and therapeutic implications of hypermutation in gliomas
Mechanisms and therapeutic implications of hypermutation in gliomas
Mehdi Touat, Yvonne Y. Li, Adam N. Boynton, Liam F. Spurr, J. Bryan Iorgulescu, ..., Ahmed Idbaih, Rameen Beroukhim, Pratiti Bandopadhayay, Franck Bielle, Keith L. Ligon
Nature   ·   15 Apr 2020   ·   doi:10.1038/s41586-020-2209-9

2019

Neuronal differentiation and cell-cycle programs mediate response to BET-bromodomain inhibition in MYC-driven medulloblastoma
Neuronal differentiation and cell-cycle programs mediate response to BET-bromodomain inhibition in MYC-driven medulloblastoma
Pratiti Bandopadhayay, Federica Piccioni, Ryan O’Rourke, Patricia Ho, Elizabeth M. Gonzalez, ..., Jacob D. Jaffe, David E. Root, Kimberly Stegmaier, Cory M. Johannessen, Rameen Beroukhim
Nature Communications   ·   03 Jun 2019   ·   doi:10.1038/s41467-019-10307-9

2018

Specific <sup>18</sup>F-FDHT Accumulation in Human Prostate Cancer Xenograft Murine Models Is Facilitated by Prebinding to Sex Hormone–Binding Globulin
Specific 18F-FDHT Accumulation in Human Prostate Cancer Xenograft Murine Models Is Facilitated by Prebinding to Sex Hormone–Binding Globulin
Benjamin M. Larimer, Frank Dubois, Emily Bloch, Sarah Nesti, Michael Placzek, Giorgia Zadra, Jacob M. Hooker, Massimo Loda, Umar Mahmood
Journal of Nuclear Medicine   ·   31 May 2018   ·   doi:10.2967/jnumed.118.208785