Publications

Highlighted

Structural variations in cancer and the 3D genome

Frank Dubois, Nikos Sidiropoulos, Joachim Weischenfeldt, Rameen Beroukhim

Nature Reviews Cancer · 28 Jun 2022 · doi:10.1038/s41568-022-00488-9

Structural variants shape driver combinations and outcomes in pediatric high-grade glioma

Frank P. B. Dubois, Ofer Shapira, Noah F. Greenwald, Travis Zack, Jeremiah Wala, ..., David T. W. Jones, Mark W. Kieran, Keith L. Ligon, Rameen Beroukhim, Pratiti Bandopadhayay

Nature Cancer · 04 Jul 2022 · doi:10.1038/s43018-022-00403-z

All

2024

Passenger Gene Coamplifications Create Collateral Therapeutic Vulnerabilities in Cancer

Yi Bei, Luca Bramé, Marieluise Kirchner, Raphaela Fritsche-Guenther, Severine Kunz, ..., Jennifer Kirwan, Anja I.H. Hagemann, Philipp Mertins, Jan R. Dörr, Anton G. Henssen

Cancer Discovery · 13 Jan 2024 · doi:10.1158/2159-8290.CD-23-1189

2023

Genomic sequence context differs between germline and somatic structural variants allowing for their differentiation in tumor samples without paired normals

Wolu Chukwu, Siyun Lee, Alexander Crane, Shu Zhang, Ipsa Mittra, Marcin Imielinski, Rameen Beroukhim, Frank Dubois, Simona Dalin

Cold Spring Harbor Laboratory · 12 Oct 2023 · doi:10.1101/2023.10.09.561462

<i>ALK</i> Amplification and Rearrangements Are Recurrent Targetable Events in Congenital and Adult Glioblastoma

ALK Amplification and Rearrangements Are Recurrent Targetable Events in Congenital and Adult Glioblastoma

Anne-Florence Blandin, Ross Giglio, Maya Srikanth Graham, Guadalupe Garcia, Seth Malinowski, ..., Ralf Kittler, Robert Bachoo, Pratiti Bandopadhayay, Rameen Beroukhim, Keith L. Ligon

Clinical Cancer Research · 13 Feb 2023 · doi:10.1158/1078-0432.CCR-21-3521

2022

Assessing and improving the validity of COVID-19 autopsy studies - A multicentre approach to establish essential standards for immunohistochemical and ultrastructural analyses

Susanne Krasemann, Carsten Dittmayer, Saskia von Stillfried, Jenny Meinhardt, Fabian Heinrich, ..., Frank L. Heppner, Peter Boor, Helena Radbruch, Michael Laue, Markus Glatzel

eBioMedicine · 01 Sep 2022 · doi:10.1016/j.ebiom.2022.104193

Therapeutic targeting of ATR in alveolar rhabdomyosarcoma

Heathcliff Dorado García, Fabian Pusch, Yi Bei, Jennifer von Stebut, Glorymar Ibáñez, ..., Kerstin Haase, Michela DiVirgilio, Monika Scheer, Michael V. Ortiz, Anton G. Henssen

Nature Communications · 25 Jul 2022 · doi:10.1038/s41467-022-32023-7

FOXR2 Is an Epigenetically Regulated Pan-Cancer Oncogene That Activates ETS Transcriptional Circuits

Jessica W. Tsai, Paloma Cejas, Dayle K. Wang, Smruti Patel, David W. Wu, ..., Claudia L. Kleinman, Henry Long, David T.W. Jones, Pratiti Bandopadhayay, Timothy N. Phoenix

Cancer Research · 08 Jul 2022 · doi:10.1158/0008-5472.CAN-22-0671

Structural variants shape driver combinations and outcomes in pediatric high-grade glioma

Frank P. B. Dubois, Ofer Shapira, Noah F. Greenwald, Travis Zack, Jeremiah Wala, ..., David T. W. Jones, Mark W. Kieran, Keith L. Ligon, Rameen Beroukhim, Pratiti Bandopadhayay

Nature Cancer · 04 Jul 2022 · doi:10.1038/s43018-022-00403-z

Structural variations in cancer and the 3D genome

Frank Dubois, Nikos Sidiropoulos, Joachim Weischenfeldt, Rameen Beroukhim

Nature Reviews Cancer · 28 Jun 2022 · doi:10.1038/s41568-022-00488-9

PPM1D mutations are oncogenic drivers of de novo diffuse midline glioma formation

Prasidda Khadka, Zachary J. Reitman, Sophie Lu, Graham Buchan, Gabrielle Gionet, ..., Hasmik Keshishian, Keith L. Ligon, Steven A. Carr, Timothy N. Phoenix, Pratiti Bandopadhayay

Nature Communications · 01 Feb 2022 · doi:10.1038/s41467-022-28198-8

2020

Histone H3.3G34-Mutant Interneuron Progenitors Co-opt PDGFRA for Gliomagenesis

Carol C.L. Chen, Shriya Deshmukh, Selin Jessa, Djihad Hadjadj, Véronique Lisi, ..., Dominik Sturm, David T.W. Jones, Paolo Salomoni, Claudia L. Kleinman, Nada Jabado

Cell · 01 Dec 2020 · doi:10.1016/j.cell.2020.11.012

MR Imaging Correlates for Molecular and Mutational Analyses in Children with Diffuse Intrinsic Pontine Glioma

C. Jaimes, S. Vajapeyam, D. Brown, P.-C. Kao, C. Ma, ..., K.L. Ligon, S. Chi, M.W. Kieran, K.D. Wright, T.Y. Poussaint

American Journal of Neuroradiology · 01 May 2020 · doi:10.3174/ajnr.A6546

Mechanisms and therapeutic implications of hypermutation in gliomas

Mehdi Touat, Yvonne Y. Li, Adam N. Boynton, Liam F. Spurr, J. Bryan Iorgulescu, ..., Ahmed Idbaih, Rameen Beroukhim, Pratiti Bandopadhayay, Franck Bielle, Keith L. Ligon

Nature · 15 Apr 2020 · doi:10.1038/s41586-020-2209-9

2019

Neuronal differentiation and cell-cycle programs mediate response to BET-bromodomain inhibition in MYC-driven medulloblastoma

Pratiti Bandopadhayay, Federica Piccioni, Ryan O’Rourke, Patricia Ho, Elizabeth M. Gonzalez, ..., Jacob D. Jaffe, David E. Root, Kimberly Stegmaier, Cory M. Johannessen, Rameen Beroukhim

Nature Communications · 03 Jun 2019 · doi:10.1038/s41467-019-10307-9

2018

Specific <sup>18</sup>F-FDHT Accumulation in Human Prostate Cancer Xenograft Murine Models Is Facilitated by Prebinding to Sex Hormone–Binding Globulin

Specific ¹⁸F-FDHT Accumulation in Human Prostate Cancer Xenograft Murine Models Is Facilitated by Prebinding to Sex Hormone–Binding Globulin

Benjamin M. Larimer, Frank Dubois, Emily Bloch, Sarah Nesti, Michael Placzek, Giorgia Zadra, Jacob M. Hooker, Massimo Loda, Umar Mahmood

Journal of Nuclear Medicine · 31 May 2018 · doi:10.2967/jnumed.118.208785